These are all the connections in a mouse brain the size of a grain of sand


The previous wiring diagram, as we know, has mapped the “connection group” Drosophila And the human brain. One reason MICrONS is so popular is that the data set has the potential to improve scientists’ understanding of the brain and may help them treat brain diseases.

Venkatesh Muti, A professor of molecular and cell biology at Harvard University who studies neuronal activity in mice but did not participate in the study, he said that the project gave him and other scientists a “bird’s-eye view” of how individual neurons interact, providing a very high level of amplification they can The resolution “freeze frame” the image.

R. Clay ReidA senior researcher at the Allen Institute and another chief scientist of the MICrONS project said that before the completion of the project’s research, he would think that this level of reconstruction is impossible.

Reid said that through machine learning, the process of transforming the brain’s two-dimensional wiring diagram into a three-dimensional model has become even better. “This is an interesting combination of a very old field and a new approach,” he said.

Reid compared the new images with the first images of the human genome because they provide the basics for others. He envisions that they can help others see the structures and relationships within the brain that were previously invisible.

“I think this is the beginning in many ways,” Reid said. “Anyone with an internet connection and a computer can use this data and these AI-driven reconstructions to ask a series of extraordinary questions about the brain.”



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