Antibodies are being created to fight disease in new ways


About halfway through By 2022, we will witness a series of major breakthroughs in which we can design the human immune system to fight diseases.The pandemic has led to the development of new types vaccine, Such as those based on mRNA, Next year will expand its scope of use to protect us from other pathogens. But we will also see other ways to use the immune system to fight disease.

One of them will be the new Antibody drugsThe human body produces antibodies during infection. We have found a way to use artificially made antibodies to mark cancer cells for destruction. We can also increase the body’s immune cells’ response to cancer or suppress the immune activity that causes rheumatoid arthritis problems. In fact, antibodies are already the basis for seven out of ten of the most profitable drugs in the world.

The way these antibodies are used takes advantage of their natural ability to target specific targets. The design of the antibody itself is relatively unaffected. In 2022, all of this will change.

Now, using genetic engineering or through chemical separation and recombination of protein parts, we have the tools to change the basic structure of antibodies. These will enable us to produce various antibody-based drugs. For example, we will be able to make antibodies that can recognize and attach to three different targets at the same time—perhaps cancer cells, a receptor protein that activates immune cells, and another immune cell protein that enhances response. Already in development is an antibody that can lock three different parts of the outer coating of a virus (such as HIV). This should make it harder for the virus to mutate and avoid becoming a target.

Another immune-based drug that will stand out in 2022 is CAR T cell therapy. Here, T cells are extracted from the patient’s blood and genetically manipulated to give them a new receptor for the patient’s own cancer. The modified T cells are then returned in the hope that they can now kill the patient’s cancer cells. To a certain extent, this type of treatment has been used: some children or young people with B-cell acute lymphoblastic leukemia have received CAR T-cell therapy, and some amazing results have been achieved, but some patients have also appeared Undesirable side effects and recurrence. Next year, this therapy will be expanded by using different types of immune cells or different versions of receptors. For example, CAR T cells can be modified to kill a problematic subset of the body’s own immune cells that cause autoimmune diseases.

Our continued understanding of the immune system will also enable us to develop new diagnostic tools. Artificial intelligence has provided us with an unprecedented depth of immune cell analysis. It also helps us to correlate their parameters with, for example, the severity of a person’s symptoms of coronavirus. Next year, we will be able to look for immune signatures associated with severe cases of Covid-19 and other diseases, and be able to predict the trajectory of the disease and adjust treatment accordingly. In 2022 and beyond, our understanding of the immune system will continue to increase, which will give birth to new drugs and new medical methods.

Get more experts’ predictions for the coming year. The wired world in 2022 With intelligence and insights that need to be known from the brightest minds in the WIRED network.It’s now available on newsstands as Digital downloadOr you can Order your copy online.

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