How does the endocannabinoid (ECS) system work?


The endocannabinoid system (ECS) is a biological system that plays an important role in regulating various processes and functions in the human body (including mood, sleep, appetite, memory, and reproduction and fertility).Even if we don’t consume marijuana or CBD productsAnd have is called “Participate in the establishment and maintenance of the most important physiological system for human health.” Please continue reading to learn more about ECS and how it works.

How to discover the endocannabinoid system?

In 1988, a study funded by the US government at St. Louis University School of Medicine found that mammalian brains have receptor sites that respond to compounds present in cannabis. Scientists are trying to understand how THC (the substance in cannabis that makes people feel “high”) affects the human body. They discovered an extensive network of cannabinoid receptors (CBr) in the surrounding and central nervous system cells.

Cannabinoid receptors are located on the surface of our cells and monitor what is happening inside and outside the cells. They transmit information about these changes to the inside of the cell, thereby prompting an appropriate cellular response. The two main cannabinoid receptors are called CB-1 and CB-2. Although there are more, these are the first two to be discovered and are still the most thoroughly researched.

The discovery of these receptors raises a puzzling question: If no naturally occurring cannabinoids can bind to them, why does the body need to produce them? Further research found that the human body produces cannabinoid-like chemicals that interact with receptors.The first thing to make sure is Anamamide, A fatty acid neurotransmitter, plays a role in regulating appetite and nerve production of pleasure and motivation, and acts as Natural antidepressant In the body.

The third part of ECS is the metabolic enzymes that break down endocannabinoids after use. These enzymes ensure that endocannabinoids are used when needed, but not for longer than necessary for any process in which they occur.

What is the role of the endocannabinoid system?

To understand ECS, we first need to understand dynamic balance. Homeostasis is the process by which your body tries to keep everything in the right area. It tries to keep everything happening inside the body in a stable and optimal state, regardless of what happens outside and around. Your body will constantly work to monitor the important functions and levels: Is your hormone level correct? Is your temperature too high or too low? Do you need food? Do you need to sleep?

When something in your body breaks down, ECS will step in to correct the problem. Therefore, if you are too cold, you will start to tremble to warm your body. If it is too hot, you will start to sweat to cool down. If the stomach is uncomfortable, you know you need to eat. Homeostasis is also called the “Goldlock Zone”-because everything is “just right”. The working principle of ECS is very precise, it can maintain homeostasis, and only affect the required balance. So, for example, if you have a problem with your digestive system, it will only be activated to regulate the problem, without affecting your immune system or reproductive hormones.

Homeostasis is essential to human health, and ECS is an important part of our well-being.Scientific research has shown that ECS activities related to many different diseases have changed, including cancer, Neurodegenerative diseases with Rheumatoid Arthritis. Due to the impact of cannabis products on ECS, they have quickly become obvious and important targets for potential therapies, and extensive research is underway to find their possible health benefits.

As scientists conducted more research in ECS, they discovered several diseases that may be related to the lack of naturally occurring endocannabinoids, called Clinical cannabinoid deficiency (CECD). There is evidence that CECD may work on conditions including irritable bowel syndrome, migraine and fibromyalgia.Research is ongoing to find out how CBD products And medical marijuana may be able to correct CECD. However, cannabinoids are also being studied as potential treatments for many other diseases, not only those related to CECD, including Alzheimer’s disease, mental illness, cardiovascular disease, chronic pain and kidney disease, to name a few.

How does the endocannabinoid system respond to THC?

Tetrahydrocannabinol (THC) is one of the main natural compounds found in cannabis. This is a compound that produces a feeling of “high” and causes the sensations normally associated with cannabis use, such as relaxation, happiness, giggles, or hunger. Like the cannabinoids mentioned above, THC interacts with the cannabinoid system by binding to the CB1 and CB2 receptors. Because it can bind to two receptors, it has a powerful and diverse range of action. Some of these effects are desirable and pleasurable sensations, such as relief of pain and feelings of elevated. However, not all feelings produced by THC are good. THC can bind to receptors in the amygdala of the brain, thereby helping to regulate anxiety, stress, fear and other related emotions.Excess cannabinoids may Excessive stimulation of the amygdala, Causing anxiety and paranoia.

How does it react to CBD?

Another major compound found in cannabis is cannabidiol (CBD).This is the method used to create CBD products that you can legally buy, for example oil or chewing gumies. Unlike THC, CBD does not have the properties of producing high energy, and usually does not cause any negative effects. Although experts do not yet know exactly how CBD interacts with ECS, they do know that CBD does not bind to CB1 or CB2 receptors like THC. Instead, it is believed that CBD can inhibit the breakdown of endocannabinoids such as cannabinoids. This leads to a higher concentration of endocannabinoids in the system, in other words, it leads to increased happiness and well-being. Some scientists have also put forward a theory that CBD does bind to the receptor, but the receptor has not yet been discovered. Either way, CBD has been shown to provide the health benefits of cannabis without the psychoactive THC normally associated with it.

The endocannabinoid system is essential to help the body maintain homeostasis (the “gorse zone”) and regulate processes and functions (such as mood, sleep, memory, pain, and appetite). If the cells deviate from the Goldilocks zone, the endocannabinoid system will drive the body to restore homeostasis. The cannabinoid system may also be affected by the foreign compounds THC and CBD in cannabis. CBD prevents the breakdown of endocannabinoids naturally present in the body, thereby increasing their lifespan in the body and thus bringing benefits, and is particularly effective in helping ECS. CBD products provide the benefits of naturally occurring compounds in hemp without the psychoactive properties of THC. Although there is still a long way to go to find out how CBD interacts with ECS, it is already clear that it provides tremendous benefits to our health and well-being.



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About the Author: Agnes Zang