Novel sex-determination mechanism revealed in mammals – QNT Press Release

The Sox9 gene is upregulated in the absence of sex-determining Y chromosome and Sry gene in Amami spiny rat, according to a new study led by Hokkaido University, Japan.

SAPPORO, Japan, Nov. 28, 2022 /PRNewswire/ — In mammals, the distinction between male and female at the chromosome level is due to the X and Y chromosomes. Typically, females have two X chromosomes (XX) while males have an X and a Y chromosome (XY). The Sry gene on the Y chromosome triggers the formation of the tests. However, there exist a handful of rodent species in which the Y chromosome has disappeared, taking with it the Sry gene. The mechanism by which testes development occurs in these species is not fully understood, and is subject to much research.

A team of researchers led…

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